Microtubule Dynamics Inhibitors

1. Microtubule-targeting agents impair kinesin- 2-dependent nuclear transport of β- catenin: Evidence of inhibition of Wnt/β-catenin signaling as an important antitumor mechanism of microtubule- targeting agents, Anuradha Kumari, Omprakash Shriwas, Shailendra Sisodiya, Manas K. Santra, Sankar K. Guchhait, Rupesh Dash, Dulal Panda, The FASEB Journal, 2021, 35, 1-16. https://doi.org/10.1096/fj.202002594R

2. C12, a combretastatin-A4 analog, exerts anticancer activity by targeting microtubules; Anuradha Kumari, Shalini Srivastava, Rajesh K. Manne, Shailendra Sisodiya, Manas K. Santra, Sankar K.Guchhait, Dulal Panda, Biochem. Pharmacol., 2019, 170, 113663.

3. C-12 Binds to Tubulin at the Colchicine-binding Site and Target Microtubules by Preferentially Binding to GTP-bound Tubulin, Shweta Shyam Prassanawar, Anuradha Kumari, Sankar K Guchhait, Dulal Panda, The FASEB Journal, 2019, 1, 784.14.

4. Combretastatin-Inspired Heterocycles as Antitubulin Anticancer Agents, Neha Hura, Avishkar V. Sawant, Anuradha Kumari, Sankar K. Guchhait, and Dulal Panda, ACS Omega 2018, 3, 9754−9769.

5. A Combretastatin Analogue C12 Binds to Colchicine Site in Tubulin, Inhibits Spindle Microtubule Dynamics, Activates Mitotic Checkpoint and Induces Apoptosis in Cancer Cells, Anuradha Kumari, Shalini Srivastava, Shweta Shyam Prassanawar, Shailendra Sisodiya, Sankar K.Guchhait, Dulal Panda, Biophysical Journal 2018, 114, 415.

6. Drug-Clinical Agent Molecular Hybrid: Synthesis of Diaryl(trifluoromethyl)pyrazoles as Tubulin Targeting Anticancer Agents, Neha Hura, Afsana Naaz, Shweta S. Prassanawar, Sankar K. Guchhait, and Dulal Panda; ACS Omega 2018, 3, 1955−1969.

7. Novel combretastatin–2-aminoimidazole analogues as potent tubulin assembly inhibitors: Exploration of unique pharmacophoric impact of bridging skeleton and aryl moiety, Vikas Chaudhary, Jubina Balan Venghateri, Hemendra Pal Singh Dhaked, Anil Shamraj Bhoyar, Sankar K Guchhait, Dulal Panda, J. Med. Chem. 2016, 59, 3439−3451.

8. Combretastatin A-4 Inspired Novel 2-Aryl-3-arylamino-imidazopyridines/pyrazines as Tubulin Polymerization Inhibitors, Antimitotic and Anticancer Agents, Sanghai, N.; Jain, V.; Preet, R.; Kandekar, S.; Das, S.; Trivedi, N.; Mohapatra, P.; Priyadarshani, G.; Kashyap, M.; Das, D.; Sathapathy, S, R.; Sidharth, S.; Guchhait, S. K.; Kundu. C.; Bharatam, P. V. Med. Chem. Commun. 2014, 5, 766-782.