Research Interests

Research Area: Synthetic Organic Medicinal Chemistry

• Anticancer drug discovery: Design and synthesis of heterocyclic compounds as human DNA topoisomerase IIα inhibitors, Microtubule-dynamics inhibitors, DNA polymerases inhibitors, and their SAR studies

• Antileishmanial drug discovery: Design and synthesis of heterocyclic compounds as target-specific antileishmanial agents

• Network-linked polypharmacology-based drug discovery

• Natural product-inspired, Scaffold-hopping, and Choice-based change medicinal chemistry strategies

• Creating new from clinical trial agents and drugs; Exploration of patentable bioactive chemotypes

• Identification of target-specific unique pharmacophore motifs

• Structural modulations linked to pharmacodynamics, drug-likeness and pharmacokinetic-relevant physicochemical properties

• Synthesis of natural product-based compounds (structural elaborated, simplified and analog)

• Synthetic methodology development: Construction of pharmaceutically-privileged heterocyclic molecular skeletons, SAR/molecular diversity-enabled approach

• Chemistry: C-H bond functionalization, Ylide chemistry, Synthon, Isocyanide-based reactions, Catalysis, Green chemistry